The high prevalence of cardiovascular diseases demands a reliable and sensitive risk assessment technique. In order to develop a fast and label-free immunosensor for C-reactive protein, a risk factor for this condition, anti-CRP antibodies were physically adsorbed to the hydrogen -terminated surface of nanocrystalline diamond. An Enzyme-Linked ImmunoSorbent Assay reference technique showed that this was a suitable substrate for antibody-antigen recognition reactions. Electrochemical Impedance Spectroscopy was used to electronically detect CRP recognition. The specificity of the immunosensor was demonstrated by incubation (...) with CRP and plasminogen as reference molecule. A different impedance behavior was observed in real-time after CRP addition as compared to plasminogen addition: the impedance increased only during CRP incubation. Fitting the data showed that this corresponded with a decrease in capacitance of the molecular layer due to its increased thickness by specific CRP recognition. Sensitivity experiments in real-time showed a clear discrimination between 1 μM, 100 nM, and 10 nM of CRP after 10 min at 100 Hz. Since, 10 nM of CRP was still clearly distinguishable from buffer solution, our CRP-directed immunosensor prototype reaches a sensitivity that is within the physiologically relevant concentration range of this biomarker in healthy controls and CVD patients. Moreover, this prototype displayed real-time discriminating power between spiked and unspiked serum, and thus also shows its applicability in this biological matrix. © 2011 Elsevier B.V. All rights reserved. (shrink)

The author discusses the effects of contraception, which have borne out the predictions of Pope Paul VI's encyclical Humanae Vitae: the explosion of out-of-wedlock births, lack of respect for women, STD's, HIV/AIDS, etc. The overpopulation claims that fed the acceptance and promotion of contraception have been discredited by demographers; now the social costs of underpopulation are increasingly apparent. Acceptance of contraception has now also led to an embracing of morally objectionable technologies like cloning. This is the latest consequence of the (...) separation of sex and reproduction signaled by the acceptance of contraception. (shrink)

Contemporary yoga is popularly represented in various media by a fit, white woman. Yoga Journal is a magazine recognized by many as an industry cornerstone and an institution in and of itself. It represents the distinctive face of yoga. By analyzing the visual and textual content of the Yoga Journal magazine covers, from its first issue in 1975 to issue 313, we describe the produced and consumed portrait of yoga. By focusing on the cover themes, together with the objects and (...) persons depicted, we recognize three phases of development that have contributed to the understanding of the changing image of yoga in the media. While, in the initial phase, yoga was represented as a mystical and mysterious spiritual discipline that originated in the Orientalized East, in the later phase, it was depicted first as a global and universal phenomenon and then as a mainstream everyday fitness regime. Yoga’s depiction in the last phase is compatible with the scholarly representation of contemporary yoga as posture and body centered, but not with its earlier depictions. We found that in its mature phase, the yoga body, which is criticized for its lack of inclusiveness, emerged to become omnipresent. We conclude that the newly formed face of yoga is problematic, both for its female readers, who are encouraged to conform to a unique body type, and also for the yoga community, which encounters an appearance-based restriction of access. (shrink)

As terms, “Yoga” and “Zen” are as ubiquitous as they are banal. They float, freely, empty of any real meaning. Just about anything could be, Zen; in the same way that, just about anything could be, Yoga. In a closed loop, one might even define “Yoga” as “like Zen” or “Zen” to be a form of “Yoga.” However, in various ways, they are forged into a new hybrid. The marketing of syncretic, yoga-inflected Buddhist temple tourist options in and around Kyoto, (...) Japan, demonstrates how “Zen+Yoga” hybrids have become trans-glocal phenomena stretching between London and Sydney. Why does the Zen+Yoga hybrid seem to receive less criticism than other X+Yoga hybrids, such as Goat+Yoga, Beer+Yoga, SUP+Yoga, Death Metal+Yoga, Dog+Yoga, and, to a lesser extent, Hot+Yoga? A significant part of the Zen+Yoga hybrid’s ability to heretically seal itself from criticism is due to the institutionalized religious capital that schools of Zen Buddhism have. Even though the other X+Yoga hybrids rely on similar discursive and haptic logics, they are unconstrained by tradition and institution, unlike Zen. While all hybrids are novel branding attempts for attention from within a thoroughly saturated wellness tourism market, syncretic X+Yoga hybrids are not new. Neither are they universally accepted as heretical cultural appropriations. The common assumption regarding the commensurability of Zen and Yoga practices at epistemological, ontological, and soteriological levels is challenged. As well as, the social, political, and economic realities of tourism and temples are analyzed. This is based on 2 years of ethnographic and specific media content analysis regarding Japan’s yogascapes. This paper focuses the discussion on Tera Yoga. (shrink)

Over the last two decades, the various attempts to “radicalize” Levinas have resulted in two interesting and often separated debates: one the one hand, there is the debate regarding the relationship between Levinas and colonialism and racism, and on the other hand, there is the debate regarding the relationship between Levinas and Judaism. Whether scholars interested in issues of colonialism disregard Levinas's Judaism or use his "subaltern" identity to challenge European hegemony, they do not take seriously the Jewish content of (...) Levinas's thought. In this essay, I challenge the prevailing postcolonial orinetation of the Levinas-colonialism conversation, approaching Levinas's phenomenology from an anticolonial perspective. I will use Frantz Fanon’s dualistic understanding of the colonial world to evaluate the adequacy of Levinas’s phenomenology in describing the ontological structure of the colony and the historical experience of the colonized within it. Levinas’s incomplete understanding of the Holocaust as colonialism contributes to his failure to recognize the dividing line of colonial ontology, the zone of nonbeing, the non-human status of the colonized, and ultimately contributes to the insufficiency of his phenomenology to describe the colony. Because my purpose is not to reject Levinas’s thought in general but to encourage a new approach to his work, in the conclusion I will gesture toward the need for an anticolonial reading of Levinas’s project for Jewish education. (shrink)

WikiLeaks is among the most controversial institutions of the last decade, and this essay contributes to an understanding of WikiLeaks by revealing the philosophical paradigm at the foundation of Julian Assange’s worldview: cypherpunk ethics. The cypherpunk movement emerged in the early-1990s, advocating the widespread use of strong cryptography as the best means for defending individual privacy and resisting authoritarian governments in the digital age. For the cypherpunks, censorship and surveillance were the twin evils of the computer age, but they viewed (...) encryption as a means to circumvent both. As a cypherpunk, Assange advocates for the use of cryptography in the fight for individual privacy as well as the fight for global justice. His cosmopolitan disposition is informed by his hacker background, antiwar principles, and Enlightenment outlook. This essay places Assange’s philosophical idea in historical context, exploring his views on censorship, surveillance, and the right to communicate. It also connects his cypherpunk principles to WikiLeaks, showing that the strategy of encouraging data leaks from powerful political and economic organizations is classic cypherpunk political praxis. (shrink)

ObjectiveOverweight and obesity [body mass index ≥ 25 kg/m2] are associated with poorer prognosis among women with breast cancer, and weight gain is common during treatment. Symptoms of depression and anxiety are also highly prevalent in women with breast cancer and may be exacerbated by post-diagnosis weight gain. Altered brain function may underlie psychological distress. Thus, this secondary analysis examined the relationship between BMI, psychological health, and resting state functional connectivity among women with breast cancer.MethodsThe sample included 34 post-menopausal women (...) newly diagnosed with Stage 0-IIa breast cancer who were enrolled in a 6-month randomized controlled trial of aerobic exercise vs. usual care. At baseline prior to randomization, whole-brain analyses were conducted to evaluate the relationship between BMI and seed-to-voxel rsFC of the hippocampus and amygdala. Connectivity values from significant clusters were then extracted and examined as predictors of self-reported depression and anxiety.ResultsMean BMI was in the obese range. For both seeds examined, higher BMI was associated with lower rsFC with regions of prefrontal cortex, including ventrolateral PFC, dorsolateral PFC, and superior frontal gyrus. Hippocampal connectivity with the vlPFC was negatively correlated with self-reported anxiety.ConclusionHigher BMI was associated with lower hippocampal and amygdala connectivity to regions of PFC implicated in cognitive control and emotion regulation. BMI-related differences in hippocampal and amygdala connectivity following a recent breast cancer diagnosis may relate to future worsening of psychological functioning during treatment and remission. Additional longitudinal research exploring this hypothesis is warranted. (shrink)

This study is a reading of Lonergan on "system and history," a topic central to his thought. The study begins by establishing two preliminary contexts. First, it constructs an overview of the problematic in chapter one. Second, it establishes a further context in chapter two by analyzing his writings on the topic in 1959, the year he gave a graduate seminar on "System and History." Subsequent chapters trace the emergence in the history of Lonergan's thought of historical heuristics, of historical (...) maieutics, and of the relation of both in his theory and philosophy of history. ;The study largely prescinds, however, from Lonergan's theory of the dialectic of history. Instead, it draws attention to the role of the emergence of an adequate human science in what Lonergan calls "the challenge of history," that is, the challenge of decreasing the role of mere chance and fate in history while increasing the role of conscious grasp and deliberate choice. Meeting that challenge requires, as Lonergan insists, "a human science that is concerned, to adapt a phrase from Marx, not only with knowing history but also with directing it." Lonergan considered the needed human science at once a possible project and "a vastly ambitious task." The needed human science involves "a critique of history" in the service of the "intelligent direction of history," and Lonergan holds some combination of the two central to a practical theory of history. Those two components emerge first in historical and economic manuscripts Lonergan wrote in the 1930s as examined in chapter three of the study. Chapter four examines those topics in Insight, together with Lonergan's view that emergent probability generically determines the course of human history. Chapter five examines the relation of historical scholarship to the need for an upper blade of historical heuristics in the period between Insight and Method. Finally, chapter six explores how the themes of historical heuristics and historical maieutics meet, albeit in subtle ways, in Lonergan's Method in Theology. (shrink)

As companies increasingly communicate CSR initiatives through social media, viral message propagation has become a crucial prerequisite for CSR success. Evidence from two experimental studies, one based on a national representative online sample, shows that social media peers’ endorsement of a CSR message in terms of number of shares, likes and positive replies contributes to an individual’s intention to share it on the social network and thereby participate in message propagation, and that this process can be explained by normative influences (...) exerted by the social media community through the activation of injunctive and descriptive norms, as well as social identity motives. Findings further confirmed that the norm-activating effects of social media endorsement are moderated by the empowering qualities of the CSR message, the sharing source of the message by affecting CSR credibility, and the recipient’s interdependent self-construal. Corporate communication managers are advised to achieve a high degree of initial social media endorsement of their CSR message, for recipients of the message to perceive social pressure motivating message sharing with their social media peers. (shrink)

Ecofeminist philosophy and literary theory need mutually to enhance each other's critical praxis. Ecofeminism provides the grounding necessary to turn the Bakhtinian dialogic method into a critical theory applicable to all of one's lived experience, while dialogics provides a method for advancing the application of ecofeminist thought in terms of literature, the other as speaking subject, and the interanimation of human and nonhuman aspects of nature. In the first part of this paper the benefits of dialogics to feminism and ecofeminism (...) are explored; in the second part dialogics as method is detailed; in the third part literary examples are discussed from a dialogical ecofeminist perspective. (shrink)

BackgroundReconciling results obtained using different types of sensory measures is a challenge for autism sensory research. The present study used questionnaire, psychophysical, and neurophysiological measures to characterize autistic sensory processing in different measurement modalities.MethodsParticipants were 46 autistic and 21 typically developing 11- to 14-year-olds. Participants and their caregivers completed questionnaires regarding sensory experiences and behaviors. Auditory and somatosensory event-related potentials were recorded as part of a multisensory ERP task. Auditory detection, tactile static detection, and tactile spatial resolution psychophysical thresholds were (...) measured.ResultsSensory questionnaires strongly differentiated between autistic and typically developing individuals, while little evidence of group differences was observed in psychophysical thresholds. Crucially, the different types of measures appeared to be largely independent of one another. However, we unexpectedly found autistic participants with larger auditory Tb ERP amplitudes had reduced hearing acuity, even though all participants had hearing acuity in the non-clinical range.LimitationsThe autistic and typically developing groups were not matched on cognitive ability, although this limitation does not affect our main analyses regarding convergence of measures within autism.ConclusionOverall, based on these results, measures in different sensory modalities appear to capture distinct aspects of sensory processing in autism, with relatively limited convergence between questionnaires and laboratory-based tasks. Generally, this might reflect the reality that laboratory tasks are often carried out in controlled environments without background stimuli to compete for attention, a context which may not closely resemble the busier and more complex environments in which autistic people’s atypical sensory experiences commonly occur. Sensory questionnaires and more naturalistic laboratory tasks may be better suited to explore autistic people’s real-world sensory challenges. Further research is needed to replicate and investigate the drivers of the unexpected association we observed between auditory Tb ERP amplitudes and hearing acuity, which could represent an important confound for ERP researchers to consider in their studies. (shrink)

The ecology movement has recently attempted to reinvigorate the image of Earth in terms of Lovelock and Epton’s “Gaia hypothesis.” I analyze the shortcomings of using Gaia imagery in the works of Lovelock, deep ecologists, feminists, and ecological poets, and conclude that while the hypothesis serves to alter consciousness, naming it Gaia reinforces the oppressive hierarchical patterns of patriarchal gender stereotypes that it opposes. We are moving toward a new paradigm of nonpatriarchal pluralistic co-evolution, but if deep ecology is going (...) to promote fully its development, it needs to recast or cast aside Gaia imagery. (shrink)

This concise anthology of primary sources designed for use in an ancient philosophy survey ranges from the Presocratics to Plato, Aristotle, the Hellenistic philosophers, and the Neoplatonists. The Second Edition features an amplified selection of Presocratic fragments in newly revised translations by Richard D. McKirahan. Also included is an expansion of the Hellenistic unit, featuring new selections from Lucretius and Sextus Empiricus as well as a new translation, by Peter J. Anderson, of most of Seneca's _De Providentia_. The selections from (...) Plotinus have also been expanded. (shrink)

Many religious critics argue that biotechnology (such as cloning and genetic engineering) intrudes on God's domain, or plays God, or revolts against God. While some of these criticisms are standard complaints about human hubris, I argue that some of the recent criticism represents a “Promethean” concern, in which believers unreflectively seem to fear that science and technology are actually replicating or stealing God's special deity–defining powers. These criticisms backfire theologically, because they diminish God, portraying God as an anthropomorphic superbeing whose (...) relevance and special nature are increasingly rivaled by human power. (shrink)

The essay attempts to offer an alternative genealogy of aesthetics from the perspective of a post-colonial history. Here a painting from the Philippines, Juan Luna's Spoliarium (1884), is reworked to offer insights into this possible operation that exceeds the typical methods of relativization and the exclusively nationalist anti-colonial critique. It focuses on both art and the discourse about it, including the oration of the National Hero Jose Rizal, and how these intersect with the end of the colony and the compelling (...) emergence of the aesthetic in eccentric grounds. (shrink)

In the Decalogue, a foundation is laid for the order of the community, a foundation that continues in perpetuity to be the touchstone for all actions on the part of God's people as they seek to live in community and order their lives.

?On or about XX1100XXX2009? I arrived at Compound XX, TIF Defender, Camp Bucca Iraq and discovered that SFC XXXX and CPL XXXX had, in contravention of standard operating procedure and the requirements of Combined Joint Task Force 134 General Orders, entered Compound XX without first securing all detainees in the Salat, and walked to the rear fenceline through the occupied Compound, many times within deadspace [outside the] guard force's line of sight, and back through the sally port.1 SFC XXXX and (...) CPL XXXX were unmolested during this entry. No prior coordination was performed with the other members of the guard force, other than PFC XXXX who was ordered by SFC XXXX to open the sally port to allow entry. SFC XXXX and CPL XXXX were in a Compound occupied at the time by approximately 1038 Iraqi Security Detainees, and could have been harmed or taken hostage with little warning, leaving the guard force few options other than to attempt to defend SFC XXXX and CPL XXXX by lethal means, as these were the only weapons available that had the range and accuracy required? (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

In this issue of the Hastings Center Report, Mélanie Terrasse, Moti Gorin, and Dominic Sisti respond to recent efforts to address the “digital attention crisis,” arguing that “[b]ioethicists should make their voices heard in the debate on the responsibilities of social media companies toward their consumers and society at large.” I strongly agree. I have frequently been asked by my colleagues why I spend time on social media professionally, on top of all the competing demands associated with my work as (...) a bioethicist and medical educator. There is sometimes a dismissive tone in these questions, a sense that attention to social media is beneath a bioethicist’s proper intellectual pursuits. Such perspectives overlook the extraordinary opportunities of social media and the important role for bioethics, as a field, in examining them. (shrink)

The abortion controversy as a cultural phenomenon is itself socially troublesome. However, current biotechnology research programs point to a possible technological fix. If we could harmlessly remove fetuses from women’s bodies and transfer them to other women, cryonic suspension, or ectogenetic devices, this might mitigate the controversy. Pro-lifers’ apparent minimal requirement would be met—fetuses would not be killed. Pro-choicers’ apparent minimal requirement would be met—women could end pregnancies and control their bodies. This option has been optimistically anticipated by some ethicists, (...) but some people reject this fix because they are averse to being genetically related to a child they are not raising, insisting on the right to destroy the fetus as well as have it removed. Inthis paper I examine these issues, asking what the real issues in abortion rights are, whether technology can help, what the scope of reproductive autonomy is, and how technology will change the abortion debate. (shrink)

Written by a distinguished international team of contributors, this volume explores Shakespeare's vivid depictions of moral deliberation and individual choice in light of Renaissance debates about ethics. Examining the intellectual context of Shakespeare's plays, the essays illuminate Shakespeare's engagement with the most pressing moral questions of his time, considering the competing claims of politics, Christian ethics and classical moral philosophy, as well as new perspectives on controversial topics such as conscience, prayer, revenge and suicide. Looking at Shakespeare's responses to emerging (...) schools of thought such as Calvinism and Epicureanism, and assessing comparisons between Shakespeare and his French contemporary Montaigne, the collection addresses questions such as: when does laughter become cruel? How does style reflect moral perspective? Does shame lead to self-awareness? This book is of great interest to scholars and students of Shakespeare studies, Renaissance studies and the history of ethics. (shrink)

Random-excitation granule cells are likely to overwhelm spatiotemporal sequences described as in Braitenberg et al.'s target article. A mechanism is proposed involving the Golgi cells to reinforce tidal waves against noise. The recurrent inhibition by the Golgi calls can recruit random excitations of granule cells in phase with sequences of mossy fiber input.

Psychiatry has witnessed a new wave of approaches to clinical phenotyping and the study of psychopathology, including the National Institute of Mental Health’s Research Domain Criteria, clinical staging, network approaches, the Hierarchical Taxonomy of Psychopathology, and the general psychopathology factor, as well as a revival of interest in phenomenological psychopathology. The question naturally emerges as to what the relationship between these new approaches is – are they mutually exclusive, competing approaches, or can they be integrated in some way and used (...) to enrich each other? In this opinion piece, we propose a possible integration between clinical staging and phenomenological psychopathology. Domains identified in phenomenological psychopathology, such as selfhood, embodiment, affectivity, etc., can be overlaid on clinical stages in order to enrich and deepen the phenotypes captured in clinical staging (‘high resolution’ clinical phenotypes). This approach may be useful both ideographically and nomothetically, in that it could complement diagnosis, enrich clinical formulation, and inform treatment of individual patients, as well as help guide aetiological, prediction, and treatment research. The overlaying of phenomenological domains on clinical stages may require that these domains are reformulated in dimensional rather than categorial terms. This integrative project requires assessment tools, some of which are already available, that are sensitive and thorough enough to pick up on the range of relevant psychopathology. The proposed approach offers opportunities for mutual enrichment: clinical staging may be enriched by introducing greater depth to phenotypes; phenomenological psychopathology may be enriched by introducing stages of severity and disorder progression to phenomenological analysis. (shrink)

Medicine is often thought of as a science of the body, but it is also a science of data. In some contexts, it can even be asserted that data drive health. This article focuses on a key piece of data technology central to contemporary practices of medicine: the medical record. By situating the medical record in the perspective of its history, we inquire into how the kinds of data that are kept at sites of clinical encounter often depend on informational (...) requirements that originate well outside of the clinic, in particular in health insurance records systems. Although this dependency of today's electronic medical records on billing requirements is widely lamented by clinical providers, its history remains little studied. Following the archaeology of medicine developed by Michel Foucault in The Birth of the Clinic and expanding his methodology in light of more recent contributions to the field of media archaeology, this article excavates some of the underexplored technological conditions that help constitute today's electronic medical record. If in some contexts, it is true that data drive health, then an archaeology of medical records helps reveal how health insurance records often impact clinical care and, by extension, health and disease. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Despite the challenges associated with virtually mediated communication, remote collaboration is a defining characteristic of online multiplayer gaming communities. Inspired by the teamwork exhibited by players in first-person shooter games, this study investigated the verbal and behavioral coordination of four-player teams playing a cooperative online video game. The game, Desert Herding, involved teams consisting of three ground players and one drone operator tasked to locate, corral, and contain evasive robot agents scattered across a large desert environment. Ground players could move (...) throughout the environment, while the drone operator’s role was akin to that of a “spectator” with a bird’s-eye view, with access to veridical information of the locations of teammates and the to-be-corralled agents. Categorical recurrence quantification analysis was used to measure the communication dynamics of teams as they completed the task. Demands on coordination were manipulated by varying the ground players’ ability to observe the environment with the use of game “fog.” Results show that catRQA was sensitive to changes to task visibility, with reductions in task visibility reorganizing how participants conversed during the game to maintain team situation awareness. The results are discussed in the context of future work that can address how team coordination can be augmented with the inclusion of artificial agents, as synthetic teammates. (shrink)

This is French version of John Stuart Mill's essay "On Nature" accompanied by a introduction by the translator and a lexicon of English words (used in moral philosophy) often wrongly translated into French and a short reflection on the two senses of the word "law" that often cause confusion.

Martin Heidegger is, perhaps, the most controversial philosopher of the twentieth-century. Little has been written on him or about his work and its significance for educational thought. This unique collection by a group of international scholars reexamines Heidegger's work and its legacy for educational thought.

Partant du débat qui oppose les orientations sémiologique et esthétique, l'auteur propose une troisième voie qui, comme les deux autres, vise à rendre compte de la perception esthétique du film, mais, au lieu de s'enfermer dans l'antinomie discours-figure, ou représentation-visibilité, problématise le fait de " l'impossible à représenter " dans sa confrontation avec le langage et le visible. Ce projet peut être considéré, selon l'auteur, comme une poétique, en un sens plus radical que la notion traditionnelle ou son prolongement chez (...) les formalistes russes, étant donné le thème de " l'articulation des signifiants à l'impossible " - une poétique qui procède de la crise de la représentation dans certains films (Duras) et trouve ses principaux instruments dans la psychanalyse. La première partie du livre explore deux propositions majeures de poétique, comme étude du discours et comme approche du sensible, puis les met à l'épreuve du cinéma de Duras, avant d'utiliser les conclusions de cette partie pour instaurer un débat épistémologique autour de la théorie psychanalytique du sujet divisé, laquelle permet d'accéder à la problématique centrale du livre : la rencontre avec le réel comme impossible. Cette perspective renvoie aux travaux de Jacques Lacan sur lesquels l'auteur se fonde pour introduire sa contribution la plus personnelle : le projet d'une nouvelle poétique du cinéma. (shrink)

" Je parle. Mes mots sont des pensées qui représentent. Dans leur essence même, ces pensées sont des énoncés vrais. Il est impossible en effet que ces mots qui s'imposent au nom de ma pensée puissent, dans leur évocation même, témoigner du faux. Comment l'acte de penser, dans ce qui l'institue comme énoncé encore une fois, pourrait-il m'abuser à travers ce qui constitue son acte même d'énonciation? " Que l'on ait pu parler de " mort de la métaphysique " est (...) absolument invraisemblable ; la métaphysique, en effet, n'a jamais été aussi " vivante " qu'aujourd'hui. Que l'on puisse, tout pareillement, imaginer que l'action aujourd'hui nécessaire à effectuer dans tous les domaines du savoir soit celle d'une " déconstruction " est tout aussi déconcertant ; il s'agit bien plutôt de tout l'inverse : de reconstruire. Non pas tellement de reconstruire des modes de savoir " nouveaux " mais, plus exactement, de reconstruire les questions de méthode par lesquelles nous pensons savoir. (shrink)

We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

This volume explores how Catholicism began and continues to open its doors to the wider world and to other confessions in embracing ecumenism, thanks to the vision and legacy of the Second Vatican Council. It explores such themes as the twentieth century context preceding the council; parallels between Vatican II and previous councils; its distinctively pastoral character; the legacy of the council in relation to issues such as church-world dynamics, as well as to ethics, social justice, economic activity. Several chapters (...) discuss the role of women in the church before, during, and since the council. Others discern inculturation in relation to Vatican II. The book also contains a wide and original range of ecumenical considerations of the council, including by and in relation to Free Church, Reformed, Orthodox, and Anglican perspectives. Finally, it considers the Council’s ongoing promise and remaining challenges with regard to ecumenical issues, including a groundbreaking essay on the future of ecumenical dialogue by Cardinal Walter Kasper. (shrink)

Remontant aux sources vives de la sagesse, Patrick Mandala a choisi de confronter les textes de l'Antiquité grecque et des sages de l'Inde. Les correspondances entre ces deux philosophies sont nombreuses, riches et fécondes. Le texte grec est mis en regard avec plusieurs textes indiens. A plusieurs époques, dans sa quête de la connaissance de soi, la pensée grecque a rejoint la sagesse indienne. Cette rencontre est un message intemporel et universel. Autant de textes qui amènent la réflexion et (...) la méditation la plus profonde qui répondent aux trois grandes questions de l'humanité : "D'où venons-nous? Qui sommes-nous? Où allons-nous?". (shrink)

In this note we show that the classical modal technology of Sahlqvist formulas gives quick proofs of the completeness theorems in [8] (D. Gregory, Completeness and decidability results for some propositional modal logics containing "actually" operators, Journal of Philosophical Logic 30(1): 57-78, 2001) and vastly generalizes them. Moreover, as a corollary, interpolation theorems for the logics considered in [8] are obtained. We then compare Gregory's modal language enriched with an "actually" operator with the work of Arthur Prior now known under (...) the name of hybrid logic. This analysis relates the "actually" axioms to standard hybrid axioms, yields the decidability results in [8], and provides a number of complexity results. Finally, we use a bisimulation argument to show that the hybrid language is strictly more expressive than Gregory's language. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:diacritics 35.1 (2005) 136-146MuseSearchJournalsThis JournalContents[Access article in PDF]The Christian Bain de Diane, or the Stakes of an Ambiguous ParatextPatrick AmstutzTranslated by Gerald MooreUpon its publication, Le bain de Diane elicited few reactions on the part of criticism. Klossowski's name was still a secret and, despite its note among writers such as Bataille, Beauvoir, Camus, Parain, and Sartre and their public following, the number of readers to have read this (...) fifth work remained confined to those already familiar with Klossow-ski the essayist (Sade mon prochain, Méditations bibliques de Hamann), or the novelist (La vocation suspendue, Roberte, ce soir). The discreet silence that characterized the first reception of Le bain de Diane would last until the end of the seventies, despite a reedition in 1972 by the same publisher. During this time three important moments made Le bain de Diane resurface at the heart of the literary world: first, in fictional form, thanks to a subtle but explicit homage paid by Henri Thomas [Le promontoire]; second, in the form of a penetrating commentary article by Michel Foucault ["La prose d'Actéon"], and finally, at the hands of René Micha and Catherine Backès-Clément, key contributors to the issue that the review L'Arc dedicated to the writer. The reedition of Le bain de Diane by Gallimard1 would significantly relaunch interest in this work which, one comes increasingly to realize, is a major text in the Klossowskian oeuvre: offering a reflection on the image and writing, it was Gilles Quinsat who would open this new period of critical reception.An Uncertain IdentityQuinsat emphasizes the "series of 'tableaux' that glazes Le Bain de Diane" in accordance with a "circular" descriptive movement, he says, "from vision to commentary, attributed to the deferral without end of signs, and which feeds the entire work of Pierre Klossowski" [95]. And if he borrows the term "exegesis" from Foucault to describe the genre of the work, he immediately associates it with that of "narrative." A quarter of a century earlier, a commentary in the new Nouvelle revue française had already underlined the "disconcerting" character of Klossowski's book, by accentuating not only the strangeness of its thematic, but also the difficulties posed by the uncertainty of its generic belonging (which is echoed by the absent mention of a paratext): the critic, hesitating, suggested somewhat confusedly a typological kinship with philosophical commentary, theological scholasticism, prose poetry, series of paintings, historical narrative and even the analysis of myths [Amer 144]. In fact, this mythological "reverie," neither an essay nor a narrative, is, from this point of view, a typically Klossowskian [End Page 136] book, as Ian James has more recently reminded us [143]. Le bain de Diane mixes erudite commentary and narrative discourse so well that it entices its commentators into the traps of scholarly, historical, and philological annotation. Yet this would be to forget, as Maurice Blanchot has observed [92–94], that the written oeuvre of Klossowski belongs fully to the field of literature, even more so than to those of philosophy, theology, or psychoanalysis.When it comes to discerning the literariness of this literary object, which the different paratextual and intertextual stakes and levels underline, the principal difficulty consists in not losing oneself in a mythological labyrinth and innumerable variants of the cult of Artemis, which was one of the most significant, oldest, and popular cults of the Greco-Roman era and which plunges into a world on whose complexity historians and philologists have insisted on many occasions. The study of Klossowski's sources could lead one through multiple disciplines (philology, mythography, psychoanalysis, the history of religions, history of art, French literature—all centuries cobbled together, and so on) to overly vast inquiries: the goddess "of a thousand names" assumes a properly vertiginous semiotic richness, and the cult of Artemis, before being linked to that of Apollo, stretches back to time immemorial where, behind Artemis, can be glimpsed the Asiatic figure of a Great Mother Goddess, whose... (shrink)